https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Specific Transcriptomic Signatures and Dual Regulation of Steroidogenesis Between Fetal and Adult Mouse Leydig Cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50327 Wed 19 Jul 2023 15:35:38 AEST ]]> Sertoli cell number defines and predicts germ and Leydig cell population sizes in the adult mouse testis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33983 Wed 04 Sep 2019 09:53:56 AEST ]]> Deliverable transgenics & gene therapy possibilities for the testes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43154 Tue 13 Sep 2022 15:35:30 AEST ]]> Leukemia inhibitory factor-receptor is dispensable for prenatal testis development but is required in sertoli cells for normal spermatogenesis in mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34486 Thu 27 Jan 2022 15:56:27 AEDT ]]> Leukemia inhibitory factor-receptor signalling negatively regulates gonadotrophin-stimulated testosterone production in mouse Leydig Cells: LIFR Signalling in Leydig Cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48411 Thu 16 Mar 2023 14:04:16 AEDT ]]> Testicular cell selective ablation using diphtheria toxin receptor transgenic mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47486 Mon 23 Jan 2023 11:47:26 AEDT ]]> Sertoli cell-enriched proteins in mouse and human testicular interstitial fluid https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52812 in vivo and validated which of these are likely to arise primarily from Sertoli cells based on relevant mouse testis RNASeq datasets. We used a different, but complementary, approach to identify Sertoli cell-enriched proteins in human TIF, taking advantage of high-quality human testis genomic, proteomic and immunohistochemical datasets. We identified a total of 47 and 40 Sertoli cell-enriched proteins in mouse and human TIF, respectively, including 15 proteins that are conserved in both species. Proteins with potential roles in angiogenesis, the regulation of Leydig cells or steroidogenesis, and immune cell regulation were identified. The data suggests that some of these proteins are secreted, but that Sertoli cells also deposit specific proteins into TIF via the release of extracellular vesicles. In conclusion, we have identified novel Sertoli cell-enriched proteins in TIF that are candidates for regulating somatic cell-cell communication and testis function.]]> Fri 27 Oct 2023 15:56:20 AEDT ]]> Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44473 Fri 14 Oct 2022 08:50:28 AEDT ]]>